Inhibiting bladder tumor growth with a cell penetrating R11 peptide derived from the p53 C-terminus
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منابع مشابه
Inhibiting bladder tumor growth with a cell penetrating R11 peptide derived from the p53 C-terminus
Urothelial carcinoma of the bladder (UCB) is the most common malignancy of the urinary tract, nearly half of which contains a mutation in TP53 gene. Hence, therapeutic approach by restoring functional p53 protein in cancer cells will be beneficial. Recent studies have demonstrated the inhibition of cancer cell growth by p53 reactivation using a peptide derived from the p53 C-terminus (p53C). Ho...
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متن کاملRecovery of R11, a Novel Bladder-specific Cell Permeable Peptide, in the Rabbit Bladder and Antibiotic Efficacy of R11-tagged to Ciprofloxacin in Vitro
Hypothesis / aims of study Prior studies in a mouse model demonstrated that a new cell permeable peptide, R11, is bladder specific and can be retrieved in the bladder wall after intra-vesical instillation. This unique tissue specificity makes R11 a suitable candidate for intra-vesical antibiotic delivery for recurrent or relapsing bacterial cystitis. The rabbit bladder model is commonly used fo...
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ژورنال
عنوان ژورنال: Oncotarget
سال: 2015
ISSN: 1949-2553
DOI: 10.18632/oncotarget.5622